Post-translational modifications in signal integration.

Deribe YL, Pawson T, Dikic I
Nature structural & molecular biology 2010; 1762010Jun: 666-72


Post-translational modifications of proteins and the domains that recognize these modifications have central roles in creating a highly dynamic relay system that reads and responds to alterations in the cellular microenvironment. Here we review the common principles of post-translational modifications and their importance in signal integration underlying epidermal growth factor receptor signaling and endocytosis, DNA-damage responses and immunity.

Zugehörigkeit: Frankfurt Institute for Molecular Life Sciences and Institute of Biochemistry II, Goethe University, Frankfurt, Germany.

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