Heparin disrupts the CXCR4/SDF-1 axis and impairs the functional capacity of bone marrow-derived mononuclear cells used for cardiovascular repair.

Seeger FH, Rasper T, Fischer A, Muhly-Reinholz M, Hergenreider E, Leistner DM, Sommer K, Manavski Y, Henschler R, Chavakis E, Assmus B, Zeiher AM, Dimmeler S
Circulation research 2012; 11172012Sep14: 854-62


Cell therapy is a promising option for the treatment of acute or chronic myocardial ischemia. The intracoronary infusion of cells imposes the potential risk of cell clotting, which may be prevented by the addition of anticoagulants. However, a comprehensive analysis of the effects of anticoagulants on the function of the cells is missing.

Zugehörigkeit: Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University, Haus 25, 4. Stock, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.

Aritkel auf PubMed

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