Home > Publikationen > 2016 > 27059026

Selective AKT Inhibition by MK-2206 Represses Colorectal Cancer-Initiating Stem Cells.

Malkomes P, Lunger I, Luetticke A, Oppermann E, Haetscher N, Serve H, Holzer K, Bechstein WO, Rieger MA
Annals of surgical oncology 2018; 2392016Sep: 2849-57


Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide. Growing evidence indicates that tumor-initiating cells (TICs) are responsible for tumor growth and progression. Conventional chemotherapeutics do not sufficiently eliminate TICs, leading to tumor relapse. We aimed to gain insight into TIC biology by comparing the transcriptome of primary TIC cultures and their normal stem cell counterparts to uncover expression differences.

Zugehörigkeit: Department of General Surgery, Goethe University Hospital Frankfurt, Frankfurt, Germany. patrizia.malkomes@kgu.de.

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