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Safety and feasibility of cell-based therapy of autologous bone marrow-derived mononuclear cells in plate-stabilized proximal humeral fractures in humans.

Seebach C, Henrich D, Meier S, Nau C, Bonig H, Marzi I
Journal of translational medicine 2017; 14120161115: 314


Local implantation of ex vivo concentrated, washed and filtrated human bone marrow-derived mononuclear cells (BMC) seeded onto β-tricalciumphosphate (TCP) significantly enhanced bone healing in a preclinical segmental defect model. Based on these results, we evaluated in a first clinical phase-I trial safety and feasibility of augmentation with preoperatively isolated autologous BMC seeded onto β-TCP in combination with angle stable plate fixation for the therapy of proximal humeral fractures as a potential alternative to autologous bone graft from the iliac crest.

Zugehörigkeit: Department of Trauma Surgery, Johann-Wolfgang-Goethe University, Theodor-Stern-Kai 7, Main, 60590, Frankfurt, Germany. ccseebach@googlemail.com.

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