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Switch in Laminin β2 to Laminin β1 Isoforms During Aging Controls Endothelial Cell Functions.

Wagner JUG, Chavakis E, Rogg EM, Muhly-Reinholz M, Glaser SF, Günther S, John D, Bonini F, Zeiher AM, Schaefer L, Hannocks MJ, Boon RA, Dimmeler S
Arteriosclerosis, thrombosis, and vascular biology 2018


Endothelial cells play important roles in tissue homeostasis and vascularization, a function that is impaired by aging. Here, we aim to decipher the role of the microenvironment underlying the impairment of endothelial cell functions by aging.

Zugehörigkeit: From the Institute for Cardiovascular Regeneration (J.U.G.W., E.-M.R., M.M.-R., S.F.G., D.J., F.B., R.A.B., S.D.) and Institute of Pharmacology and Toxicology (L.S.), Goethe University, Frankfurt am Main, Germany; Department of Cardiology, Internal Medicine III, Goethe University Hospital, Frankfurt am Main, Germany (E.C., A.M.Z.); Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany (S.G.); German Center of Cardiovascular Research (DZHK), Frankfurt am Main (J.U.G.W., S.F.G., A.M.Z., R.A.B., S.D.); and Institute of Physiological Chemistry and Pathobiochemistry and Cells-in-Motion Cluster of Excellence, University of Münster, Germany (M.-J.H.).

Aritkel auf PubMed

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